Season 2 Episode
- Season 2 Janet Jackson
- Season 2 Donald Elson, Kosta Trouva
- Season 2 Howie Mandel, Juliette Lewis
- Season 2 Denzel Washington, Hilary Duff
- Season 2 Tom Felton, Ne-Yo
- Season 2 David Arquette, Ashley Greene, Billy the Exterminator
- Season 2 Billy Bob Thornton, Kunal Nayyar, Ice Cube
- Season 2 Dwayne Johnson, Katie Cassidy
- Season 2 Jennifer Love Hewitt
- Season 2 Bill Cosby, Angela Kinsey, Atomic Tom
- Season 2 Charles Barkley, Brandy, Cee-Lo Green
- Season 2 Mario Lopez
- Season 2 Khloe Kardashian, Jo Frost, Nicki Minaj
- Season 2 Bob Saget, Nene Leakes, Keri Hilson
- Season 2 Alan Cumming, Chris D'Elia
- Season 2 Steve Harvey, the 88
- Season 2 Eric Stonestreet, J.B. Smoove, Dov Davidoff
- Season 2 Anna Faris, Apolo Anton Ohno, Natasha Bedingfield
- Season 2 Mila Kunis, Dr. Drew Pinsky, Chrisette Michele
- Season 2 Justin Timberlake, Stephen Dorff, Ciara
- Season 2 Xzibit, a performance from Cirque Du Soleil's "Mystere"
- Season 2 Gene Simmons, Scott Bakula, Bettye Lavette with the Ese Vatos
- Season 2 Ron Artest, will.i.am, Dean Cole
- Season 2 Jack Black, Hailee Steinfeld, Filter
- Season 2 Lauren Graham, Will Sasso, Plain White T's
- Season 2 Mary Lynn Rajskub, Maz Jobrani
- Season 2 El Debarge featuring Faith Evans, Michael Bearden & the Ese Vatos
- Season 2 David Duchovny, Kristen Schaal, Saving Abel
- Season 2 Seth Rogen, Ginnifer Goodwin, Sick Puppies
- Season 2 William H. Macy, Camille Grammer, Cali Swag District
- Season 2 Cameron Diaz, Jason Priestley, Luke Perry, Greg Fizsimmons
- Season 2 Bill Engvall, Johnny Weir, My Chemical Romance
- Season 2 Ashley Tisdale, Kevin Hart, Grace Potter & the Nocturnals
- Season 2 Vanessa Williams, Shorty Rossi
- Season 2 Jason Statham, Busy Philipps, Wiz Khalifa
- Season 2 Jennifer Love Hewitt, Guy Fieri
- Season 2 Kristen Bell, Jake Johnson, Slash
- Season 2 DeSean Jackson, the Thermals
- Season 2 Mindy Kaling, Derek Fisher, Jasper Redd, Arturo Sandoval
- Season 2 Billy Gardell, Rachel Bilson, OK Go
- Season 2 Jamie Foxx, Aubrey Plaza
- Season 2 Channing Tatum, Margaret Cho, 50 Cent with Governor
- Season 2 Joan Rivers, Greg Jennings, Baron Vaughn
- Season 2 Brad Womack, Taylor Momsen, the Pretty Reckless
- Season 2 R. Kelly, Paul Wesley, James Loney, Bobby Castillo, Tommy Davis, Kenny Landreaux, Rudy Law, Steve Lyons, Don Mattingly
- Season 2 Justin Bieber, Far East Movement
- Season 2 Liam Neeson, a performance by the Broadway cast of "Rock of Ages"
- Season 2 200th Episode - Jenni "JWoww" Farley, Jim Jefferies
- Season 2 Amar'e Stoudemire, Kate Gosselin, Sebastian Maniscaclo
- Season 2 Martin Lawrence, Jared Leto, 30 Seconds to Mars
- Season 2 Forest Whitaker, Jessica Lucas, Bobby V & Bobby Brown
- Season 2 Jason Biggs, Anne Heche
- Season 2 Owen Wilson, Aly Michalka, Terry Fator
- Season 2 Cheryl Burke, Brandon T. Jackson, John Popper & the Duskray Troubadours
- Season 2 Ron Artest, DJ Pauly D, Michelle Rodriguez, Future Funk
- Season 2 Topher Grace, Scott Disick, Cake
- Season 2 Forest Whitaker, Donald Glover, Steel Train
- Season 2 Aaron Eckhart, Malin Akerman, Eric Andre
- Season 2 Curtis Stone, Lupe Fiasco
- Season 2 Pee-wee Herman, Emanuelle Chriqui
- Season 2 Mike Tyson, Emmy Rossum, 30 Seconds to Mars
- Season 2 Jim Rome, Boney James
- Season 2 Matthew McConaughey, Micky Ward, Ron Artest featuring George Lopez, Fat Joe, B Real, Lenny and Max from Aventura and Taz
- Season 2 Bethenny Frankel, D.L. Hughley, Seether
- Season 2 Vanessa Hudgens, Sergio Mendes
- Season 2 Larry King, Brent Weinbach
- Season 2 Snoop Dogg, Brittany Snow
- Season 2 Lil Jon, Panic! At The Disco
- Season 2 Drew Carey, Sarah Shahi, Quinn Dahle
- Season 2 Lisa Lampanelli
- Season 2 Danny McBride, Camilla Luddington, Avril Lavigne
- Season 2 Kathy Griffin, Tom Felton
Lopez Tonight
4.80 60 minutes Lopez Tonight is an American late-night television talk show that was hosted by comedian George Lopez. The hour-long program premiered on November 9, 2009, on cable network TBS. Lopez was the first Mexican American to host a late-night talk show on an English-language network in the United States. The show featured audience interaction using a high-energy format. The program aired Monday through Thursday at midnight Eastern and Pacific, immediately following Conan. On August 10, 2011, TBS announced Lopez Tonight would be cancelled. The final episode aired the following night.
